DDB1- and CUL4-associated factor 4 (DCAF4)

About DDB1- and CUL4-associated factor 4

DDB1- and CUL4-associated factor 4 (DCAF4) is a protein from Homo sapiens identified by UniProt accession Q8WV16, 495 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	DDB1- and CUL4-associated factor 4
UniProt accession	Q8WV16
Gene	DCAF4
Organism	Homo sapiens
Length	495 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.46
Red cell distribution width · score 0.41
eosinophil percentage of leukocytes · score 0.40
systolic blood pressure · score 0.37
pulse pressure measurement · score 0.34
serum gamma-glutamyl transferase measurement · score 0.33
reticulocyte count · score 0.32
lean body mass · score 0.31
body mass index · score 0.31
cystatin C measurement · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WV16-F1	alphafold	PREDICTED	77.25	—

Amino-acid sequence (495 residues)

MNKSRWQSRR RHGRRSHQQN PWFRLRDSED RSDSRAAQPA HDSGHGDDES PSTSSGTAGT SSVPELPGFY FDPEKKRYFR LLPGHNNCNP LTKESIRQKE MESKRLRLLQ EEDRRKKIAR MGFNASSMLR KSQLGFLNVT NYCHLAHELR LSCMERKKVQ IRSMDPSALA SDRFNLILAD TNSDRLFTVN DVKVGGSKYG IINLQSLKTP TLKVFMHENL YFTNRKVNSV CWASLNHLDS HILLCLMGLA ETPGCATLLP ASLFVNSHPG IDRPGMLCSF RIPGAWSCAW SLNIQANNCF STGLSRRVLL TNVVTGHRQS FGTNSDVLAQ QFALMAPLLF NGCRSGEIFA IDLRCGNQGK GWKATRLFHD SAVTSVRILQ DEQYLMASDM AGKIKLWDLR TTKCVRQYEG HVNEYAYLPL HVHEEEGILV AVGQDCYTRI WSLHDARLLR TIPSPYPASK ADIPSVAFSS RLGGSRGAPG LLMAVGQDLY CYSYS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards