About Pleckstrin homology-like domain family A member 1
Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein
from Homo sapiens identified by UniProt accession
Q8WV24, 401 residues long.
MolForge cross-references it against 0 known binders and
142 disease associations.
Target properties
| Protein name | Pleckstrin homology-like domain family A member 1 |
|---|
| UniProt accession | Q8WV24 |
|---|
| Gene | PHLDA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 401 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (142)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.30
- blood urea nitrogen measurement · score 0.30
- creatinine measurement · score 0.28
- breast adenocarcinoma · score 0.23
- atrial fibrillation · score 0.21
- amyloid-beta measurement · score 0.20
- central nervous system cancer · score 0.19
- neurofibrillary tangles measurement · score 0.19
- intrathoracic organ injury · score 0.19
- glioma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WV24-F1 | alphafold | PREDICTED | 62.53 | — |
Amino-acid sequence (401 residues)
MRRAPAAERL LELGFPPRCG RQEPPFPLGV TRGWGRWPIQ KRREGARPVP FSERSQEDGR GPAARSSGTL WRIRTRLSLC RDPEPPPPLC LLRVSLLCAL RAGGRGSRWG EDGARLLLLP PARAAGNGEA EPSGGPSYAG RMLESSGCKA LKEGVLEKRS DGLLQLWKKK CCILTEEGLL LIPPKQLQHQ QQQQQQQQQQ QQQQPGQGPA EPSQPSGPAV ASLEPPVKLK ELHFSNMKTV DCVERKGKYM YFTVVMAEGK EIDFRCPQDQ GWNAEITLQM VQYKNRQAIL AVKSTRQKQQ HLVQQQPPSQ PQPQPQLQPQ PQPQPQPQPQ PQSQPQPQPQ PKPQPQQLHP YPHPHPHPHS HPHSHPHPHP HPHPHQIPHP HPQPHSQPHG HRLLRSTSNS A
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