B-cell linker protein (BLNK)

About B-cell linker protein

B-cell linker protein (BLNK) is a protein from Homo sapiens identified by UniProt accession Q8WV28, 456 residues long. MolForge cross-references it against 0 known binders and 375 disease associations.

Target properties

Protein name	B-cell linker protein
UniProt accession	Q8WV28
Gene	BLNK
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (375)

Diseases linked to this target (Open Targets).

isolated agammaglobulinemia · score 0.63
agammaglobulinemia · score 0.47
autosomal agammaglobulinemia · score 0.37
mean corpuscular volume · score 0.35
HbA1c measurement · score 0.32
endometrial cancer · score 0.23
genetic disorder · score 0.19
head and neck squamous cell carcinoma · score 0.19
coronary artery disease · score 0.16
body height · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WV28-F1	alphafold	PREDICTED	63.73	—

Amino-acid sequence (456 residues)

MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV PVEDNDENYI HPTESSSPPP EKAPMVNRST KPNSSTPASP PGTASGRNSG AWETKSPPPA APSPLPRAGK KPTTPLKTTP VASQQNASSV CEEKPIPAER HRGSSHRQEA VQSPVFPPAQ KQIHQKPIPL PRFTEGGNPT VDGPLPSFSS NSTISEQEAG VLCKPWYAGA CDRKSAEEAL HRSNKDGSFL IRKSSGHDSK QPYTLVVFFN KRVYNIPVRF IEATKQYALG RKKNGEEYFG SVAEIIRNHQ HSPLVLIDSQ NNTKDSTRLK YAVKVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards