Zinc finger protein 480 (ZNF480)

About Zinc finger protein 480

Zinc finger protein 480 (ZNF480) is a protein from Homo sapiens identified by UniProt accession Q8WV37, 535 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Zinc finger protein 480
UniProt accession	Q8WV37
Gene	ZNF480
Organism	Homo sapiens
Length	535 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
quadriplegia · score 0.07
neoplasm · score 0.03
type 2 diabetes mellitus · score 0.03
schizophrenia · score 0.01
cancer · score 0.01
anaplastic oligodendroglioma · score 0.00
Dorfman-Chanarin disease · score 0.00
anaplastic astrocytoma · score 0.00
non-alcoholic steatohepatitis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WV37-F1	alphafold	PREDICTED	70.39	—

Amino-acid sequence (535 residues)

MLCDEKAQKR RKRKAKESGM ALPQGHLTFR DVAIEFSQAE WKCLDPAQRA LYKDVMLENY RNLVSLGISL PDLNINSMLE QRREPWSGES EVKIAKNSDG RECIKGVNTG SSYALGSNAE DKPIKKQLGV SFHLHLSELE LFPDERVING CNQVENFINH SSSVSCLQEM SSSVKTPIFN RNDFDDSSFL PQEQKVHLRE KPYECNEHSK VFRVSSSLTK HQVIHTVEKP YKCNSCGKVF SRNSHLAEHC RIHTGEKPYK CNVCGKVFSY NSNFARHQRI HTREKPYECN ECGKVFSNNS YLARHQRIHA EEKPYKCNEC GKGFSHKSSL ANHWRIYTGE KPYKCDECGK AFYRIALLVR HQKIHTGEKP YKCNECGKVF IQNSHLAQHW RIHTGEKPYK CNECGKVFNQ LSNLARHRRI HTGEKPYKCN ECGKAFSEYS GLSAHLVIHT GEKPYKCSEC GKAFRHKLSL TNHQRIHTGE RPYKCNECGK VFNRIAHLAR HRKIHTGEKP YKCNECGKAF SRISYLAQHW TIHMG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards