Sorting nexin-33 (SNX33)

About Sorting nexin-33

Sorting nexin-33 (SNX33) is a protein from Homo sapiens identified by UniProt accession Q8WV41, 574 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Sorting nexin-33
UniProt accession	Q8WV41
Gene	SNX33
Organism	Homo sapiens
Length	574 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

FEV/FVC ratio · score 0.16
Griscelli syndrome type 3 · score 0.06
erythrocyte count · score 0.06
hematocrit · score 0.06
BMI-adjusted hip circumference · score 0.06
Griscelli disease type 3 · score 0.05
Griscelli disease · score 0.05
uncombable hair syndrome · score 0.05
oculocutaneous albinism type 3 · score 0.05
Griscelli disease type 1 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WV41-F1	alphafold	PREDICTED	81.44	—

Amino-acid sequence (574 residues)

MALKGRALYD FHSENKEEIS IQQDEDLVIF SETSLDGWLQ GQNSRGETGL FPASYVEIVR SGISTNHADY SSSPAGSPGA QVSLYNSPSV ASPARSGGGS GFLSNQGSFE EDDDDDWDDW DDGCTVVEEP RAGGLGTNGH PPLNLSYPGA YPSQHMAFRP KPPLERQDSL ASAKRGSVVG RNLNRFSCFV RSGVEAFILG DVPMMAKIAE TYSIEMGPRG PQWKANPHPF ACSVEDPTKQ TKFKGIKSYI SYKLTPTHAA SPVYRRYKHF DWLYNRLLHK FTVISVPHLP EKQATGRFEE DFIEKRKRRL ILWMDHMTSH PVLSQYEGFQ HFLSCLDDKQ WKMGKRRAEK DEMVGASFLL TFQIPTEHQD LQDVEDRVDT FKAFSKKMDD SVLQLSTVAS ELVRKHVGGF RKEFQKLGSA FQAISHSFQM DPPFCSEALN SAISHTGRTY EAIGEMFAEQ PKNDLFQMLD TLSLYQGLLS NFPDIIHLQK GAFAKVKESQ RMSDEGRMVQ DEADGIRRRC RVVGFALQAE MNHFHQRREL DFKHMMQNYL RQQILFYQRV GQQLEKTLRM YDNL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards