About Pentatricopeptide repeat-containing protein 2, mitochondrial
Pentatricopeptide repeat-containing protein 2, mitochondrial (PTCD2) is a protein
from Homo sapiens identified by UniProt accession
Q8WV60, 388 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Pentatricopeptide repeat-containing protein 2, mitochondrial |
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| UniProt accession | Q8WV60 |
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| Gene | PTCD2 |
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| Organism | Homo sapiens |
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| Length | 388 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- balding measurement · score 0.17
- hair shape measurement · score 0.17
- inflammatory bowel disease · score 0.15
- alkaline phosphatase measurement · score 0.15
- asthma · score 0.14
- intraocular pressure measurement · score 0.13
- hypothyroidism · score 0.12
- appendicular lean mass · score 0.12
- lymphocyte percentage of leukocytes · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WV60-F1 | alphafold | PREDICTED | 82.50 | — |
Amino-acid sequence (388 residues)
MVRDSMAAAF RPSNRVLLQA LQILVYPGVG GSGSVSCRCP LGAKRYLLTD NVVKLKEFQQ KKVAVACNLS GTKETYFRNL KKKLTQNKLI LKGELITLLH LCESRDHVEL AKNVIYRYHA ENKNFTLGEY KFGPLFVRLC YELDLEESAV ELMKDQHLRG FFSDSTSFNI LMDMLFIKGK YKSALQVLIE MKNQDVKFTK DTYVLAFAIC YKLNSPESFK ICTTLREEAL LKGEILSRRA SCFAVALALN QNEMAKAVSI FSQIMNPESI ACINLNIIIH IQSNMLENLI KTLKNAAEGN LSKFVKRHVF SEEVLAKVRE KVKDVPALVA KFDEIYGTLH ITGQVTTDSL DAVLCHTPRD RKSHTLLLNK RMVSRRTFQP LSQSLLAE
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