About MIT domain-containing protein 1
MIT domain-containing protein 1 (MITD1) is a protein
from Homo sapiens identified by UniProt accession
Q8WV92, 249 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | MIT domain-containing protein 1 |
|---|
| UniProt accession | Q8WV92 |
|---|
| Gene | MITD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 249 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (43)
Diseases linked to this target (Open Targets).
- lipoyl transferase 1 deficiency · score 0.51
- neurodegenerative disease · score 0.44
- genetic disorder · score 0.33
- hereditary motor and sensory neuropathy · score 0.27
- Hypotonia · score 0.27
- Hearing impairment · score 0.27
- Abnormal cardiovascular system morphology · score 0.27
- Failure to thrive · score 0.27
- FEV/FVC ratio · score 0.15
- cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WV92-F1 | alphafold | PREDICTED | 91.91 | — |
Amino-acid sequence (249 residues)
MAKSGLRQDP QSTAAATVLK RAVELDSESR YPQALVCYQE GIDLLLQVLK GTKDNTKRCN LREKISKYMD RAENIKKYLD QEKEDGKYHK QIKIEENATG FSYESLFREY LNETVTEVWI EDPYIRHTHQ LYNFLRFCEM LIKRPCKVKT IHLLTSLDEG IEQVQQSRGL QEIEESLRSH GVLLEVQYSS SIHDREIRFN NGWMIKIGRG LDYFKKPQSR FSLGYCDFDL RPCHETTVDI FHKKHTKNI
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