AFG1-like ATPase (AFG1L)

About AFG1-like ATPase

AFG1-like ATPase (AFG1L) is a protein from Homo sapiens identified by UniProt accession Q8WV93, 481 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	AFG1-like ATPase
UniProt accession	Q8WV93
Gene	AFG1L
Organism	Homo sapiens
Length	481 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.19
Griscelli syndrome type 3 · score 0.09
ringed hair disease · score 0.08
uncombable hair syndrome · score 0.08
Griscelli disease · score 0.08
Griscelli disease type 3 · score 0.08
microcephaly-albinism-digital anomalies syndrome · score 0.06
Microcephaly - albinism - digital anomalies · score 0.06
pili bifurcati · score 0.06
Griscelli disease type 1 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WV93-F1	alphafold	PREDICTED	78.14	—

Amino-acid sequence (481 residues)

MAASWSLLVT LRPLAQSPLR GRCVGCGAWA AALAPLATAP GKPFWKAYTV QTSESMTPTA TSETYLKALA VCHGPLDHYD FLIKAHELKD DEHQRRVIQC LQKLHEDLKG YNIEAEGLFS KLFSRSKPPR GLYVYGDVGT GKTMVMDMFY AYVEMKRKKR VHFHGFMLDV HKRIHRLKQS LPKRKPGFMA KSYDPIAPIA EEISEEACLL CFDEFQVTDI ADAMILKQLF ENLFKNGVVV VATSNRPPED LYKNGLQRAN FVPFIAVLKE YCNTVQLDSG IDYRKRELPA AGKLYYLTSE ADVEAVMDKL FDELAQKQND LTRPRILKVQ GRELRLNKAC GTVADCTFEE LCERPLGASD YLELSKNFDT IFLRNIPQFT LANRTQGRRF ITLIDNFYDL KVRIICSAST PISSLFLHQH HDSELEQSRI LMDDLGLSQD SAEGLSMFTG EEEIFAFQRT ISRLTEMQTE QYWNEGDRTK K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards