About Chromosome transmission fidelity protein 18 homolog
Chromosome transmission fidelity protein 18 homolog (CHTF18) is a protein
from Homo sapiens identified by UniProt accession
Q8WVB6, 975 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Chromosome transmission fidelity protein 18 homolog |
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| UniProt accession | Q8WVB6 |
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| Gene | CHTF18 |
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| Organism | Homo sapiens |
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| Length | 975 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (105)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.60
- mean corpuscular hemoglobin · score 0.58
- mean reticulocyte volume · score 0.43
- hematological measurement · score 0.29
- mean corpuscular hemoglobin concentration · score 0.15
- azoospermia · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- partial chromosome Y deletion · score 0.06
- spermatogenic failure 25 · score 0.05
- spermatogenic failures 50 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WVB6-F1 | alphafold | PREDICTED | 64.11 | — |
Amino-acid sequence (975 residues)
MEDYEQELCG VEDDFHNQFA AELEVLAELE GASTPSPSGV PLFTAGRPPR TFEEALARGD AASSPAPAAS VGSSQGGARK RQVDADLQPA GSLPHAPRIK RPRLQVVKRL NFRSEEMEEP PPPDSSPTDI TPPPSPEDLA ELWGHGVSEA AADVGLTRAS PAARNPVLRR PPILEDYVHV TSTEGVRAYL VLRADPMAPG VQGSLLHVPW RGGGQLDLLG VSLASLKKQV DGERRERLLQ EAQKLSDTLH SLRSGEEEAA QPLGAPEEEP TDGQDASSHC LWVDEFAPRH YTELLSDDFT NRCLLKWLKL WDLVVFGHER PSRKPRPSVE PARVSKEATA PGKWKSHEQV LEEMLEAGLD PSQRPKQKVA LLCGPPGLGK TTLAHVIARH AGYSVVEMNA SDDRSPEVFR TRIEAATQME SVLGAGGKPN CLVIDEIDGA PVAAINVLLS ILNRKGPQEV GPQGPAVPSG GGRRRRAEGG LLMRPIICIC NDQFAPSLRQ LKQQAFLLHF PPTLPSRLVQ RLQEVSLRQG MRADPGVLAA LCEKTDNDIR ACINTLQFLY SRGQRELSVR DVQATRVGLK DQRRGLFSVW QEVFQLPRAQ RRRVGQDPAL PADTLLLGDG DAGSLTSASQ RFYRVLHAAA SAGEHEKVVQ GLFDNFLRLR LRDSSLGAVC VALDWLAFDD LLAGAAHHSQ SFQLLRYPPF LPVAFHVLFA SSHTPRITFP SSQQEAQNRM SQMRNLIQTL VSGIAPATRS RATPQALLLD ALCLLLDILA PKLRPVSTQL YSTREKQQLA SLVGTMLAYS LTYRQERTPD GQYIYRLEPN VEELCRFPEL PARKPLTYQT KQLIAREIEV EKMRRAEASA RVENSPQVDG SPPGLEGLLG GIGEKGVHRP APRNHEQRLE HIMRRAAREE QPEKDFFGRV VVRSTAVPSA GDTAPEQDSV ERRMGTAVGR SEVWFRFNEG VSNAVRRSLY IRDLL
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