E3 ubiquitin-protein ligase RNF138 (RNF138)

About E3 ubiquitin-protein ligase RNF138

E3 ubiquitin-protein ligase RNF138 (RNF138) is a protein from Homo sapiens identified by UniProt accession Q8WVD3, 245 residues long. MolForge cross-references it against 0 known binders and 122 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF138
UniProt accession	Q8WVD3
Gene	RNF138
Organism	Homo sapiens
Length	245 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (122)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
TNF-related apoptosis-inducing ligand measurement · score 0.10
azoospermia · score 0.09
glioblastoma multiforme · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.07
partial chromosome Y deletion · score 0.07
neoplasm · score 0.07
body height · score 0.07
spinocerebellar ataxia type 32 · score 0.06
spermatogenic failure 25 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WVD3-F1	alphafold	PREDICTED	78.20	—

Amino-acid sequence (245 residues)

MAEDLSAATS YTEDDFYCPV CQEVLKTPVR TTACQHVFCR KCFLTAMRES GAHCPLCRGN VTRRERACPE RALDLENIMR KFSGSCRCCA KQIKFYRMRH HYKSCKKYQD EYGVSSIIPN FQISQDSVGN SNRSETSTSD NTETYQENTS SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH LFQIVPVTCP ICVSLPWGDP SQITRNFVSH LNQRHQFDYG EFVNLQLDEE TQYQTAVEES FQVNI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards