About Transmembrane protein 171
Transmembrane protein 171 (TMEM171) is a protein
from Homo sapiens identified by UniProt accession
Q8WVE6, 324 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Transmembrane protein 171 |
|---|
| UniProt accession | Q8WVE6 |
|---|
| Gene | TMEM171 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 324 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (71)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.51
- lymphocyte count · score 0.43
- mean platelet volume · score 0.41
- gout · score 0.41
- serum urea measurement · score 0.41
- uric acid measurement · score 0.39
- blood urea nitrogen measurement · score 0.38
- neurodegenerative disease · score 0.36
- alkaline phosphatase measurement · score 0.32
- serum alanine aminotransferase measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WVE6-F1 | alphafold | PREDICTED | 55.57 | — |
Amino-acid sequence (324 residues)
MSPAAAAEPD GDQQDRHVSK LIFCFFVFGA VLLCVGVLLS IFGFQACQYK PLPDCPMVLK VAGPACAVVG LGAVILARSR AQLQLRAGLQ RGQQMDPDRA FICGESRQFA QCLIFGFLFL TSGMLISVLG IWVPGCGSNW AQEPLNETDT GDSEPRMCGF LSLQIMGPLI VLVGLCFFVV AHVKKRNTLN AGQDASEREE GQIQIMEPVQ VTVGDSVIIF PPPPPPYFPE SSASAVAESP GTNSLLPNEN PPSYYSIFNY GRTPTSEGAA SERDCESIYT ISGTNSSSEA SHTPHLPSEL PPRYEEKENA AATFLPLSSE PSPP
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