Unique cartilage matrix-associated protein (UCMA)

About Unique cartilage matrix-associated protein

Unique cartilage matrix-associated protein (UCMA) is a protein from Homo sapiens identified by UniProt accession Q8WVF2, 138 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Unique cartilage matrix-associated protein
UniProt accession	Q8WVF2
Gene	UCMA
Organism	Homo sapiens
Length	138 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

autism · score 0.12
keratoconus · score 0.11
protein measurement · score 0.09
neurodegenerative disease · score 0.08
metabolite measurement · score 0.06
Down syndrome · score 0.02
osteoarthritis · score 0.01
microphthalmia with limb anomalies · score 0.01
triple-negative breast cancer · score 0.01
chronic kidney disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WVF2-F1	alphafold	PREDICTED	81.06	—

Amino-acid sequence (138 residues)

MTWRQAVLLS CFSAVVLLSM LREGTSVSVG TMQMAGEEAS EDAKQKIFMQ ESDASNFLKR RGKRSPKSRD EVNVENRQKL RVDELRREYY EEQRNEFENF VEEQNDEQEE RSREAVEQWR QWHYDGLHPS YLYNRHHT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards