Protein phosphatase 1 regulatory subunit 1C (PPP1R1C)

About Protein phosphatase 1 regulatory subunit 1C

Protein phosphatase 1 regulatory subunit 1C (PPP1R1C) is a protein from Homo sapiens identified by UniProt accession Q8WVI7, 109 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Protein phosphatase 1 regulatory subunit 1C
UniProt accession	Q8WVI7
Gene	PPP1R1C
Organism	Homo sapiens
Length	109 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.41
hypertension · score 0.32
pulse pressure measurement · score 0.32
diastolic blood pressure · score 0.30
blood pressure · score 0.27
heart valve disease · score 0.23
Heart murmur · score 0.23
neurodegenerative disease · score 0.20
calcium measurement · score 0.18
urate measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WVI7-F1	alphafold	PREDICTED	68.80	—

Amino-acid sequence (109 residues)

MEPNSPKKIQ FAVPVFQSQI APEAAEQIRK RRPTPASLVI LNEHNPPEID DKRGPNTQGE LQNASPKQRK QSVYTPPTIK GVKHLKGQNE SAFPEEEEGT NEREEQRDH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards