About Ankyrin repeat domain-containing protein 49
Ankyrin repeat domain-containing protein 49 (ANKRD49) is a protein
from Homo sapiens identified by UniProt accession
Q8WVL7, 239 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 49 |
|---|
| UniProt accession | Q8WVL7 |
|---|
| Gene | ANKRD49 |
|---|
| Organism | Homo sapiens |
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| Length | 239 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (15)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- lung adenocarcinoma · score 0.08
- non-small cell lung carcinoma · score 0.06
- malignant glioma · score 0.06
- neoplasm · score 0.05
- insulin like growth factor measurement · score 0.04
- lymph node metastatic carcinoma · score 0.02
- squamous cell lung carcinoma · score 0.01
- glioblastoma multiforme · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WVL7-F1 | alphafold | PREDICTED | 81.63 | — |
Amino-acid sequence (239 residues)
MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD EDEEQDDKNE EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH VNTRDEDEYT PLHRAAYSGH LDIVQELIAQ GADVHAVTVD GWTPLHSACK WNNTRVASFL LQHDADINAQ TKGLLTPLHL AAGNRDSKDT LELLLMNRYV KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS
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