Dimethyladenosine transferase 1, mitochondrial (TFB1M)

About Dimethyladenosine transferase 1, mitochondrial

Dimethyladenosine transferase 1, mitochondrial (TFB1M) is a protein from Homo sapiens identified by UniProt accession Q8WVM0, 346 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Dimethyladenosine transferase 1, mitochondrial
UniProt accession	Q8WVM0
Gene	TFB1M
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
Mitochondrial non-syndromic sensorineural deafness · score 0.37
grip strength measurement · score 0.29
self reported educational attainment · score 0.24
mathematical ability · score 0.24
cognitive function measurement · score 0.19
appendicular lean mass · score 0.14
body height · score 0.14
sitting height measurement · score 0.13
vital capacity · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WVM0-F1	alphafold	PREDICTED	91.93	—

Amino-acid sequence (346 residues)

MAASGKLSTC RLPPLPTIRE IIKLLRLQAA KQLSQNFLLD LRLTDKIVRK AGNLTNAYVY EVGPGPGGIT RSILNADVAE LLVVEKDTRF IPGLQMLSDA APGKLRIVHG DVLTFKVEKA FSESLKRPWE DDPPNVHIIG NLPFSVSTPL IIKWLENISC RDGPFVYGRT QMTLTFQKEV AERLAANTGS KQRSRLSVMA QYLCNVRHIF TIPGQAFVPK PEVDVGVVHF TPLIQPKIEQ PFKLVEKVVQ NVFQFRRKYC HRGLRMLFPE AQRLESTGRL LELADIDPTL RPRQLSISHF KSLCDVYRKM CDEDPQLFAY NFREELKRRK SKNEEKEEDD AENYRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards