About Sec1 family domain-containing protein 1
Sec1 family domain-containing protein 1 (SCFD1) is a protein
from Homo sapiens identified by UniProt accession
Q8WVM8, 642 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Sec1 family domain-containing protein 1 |
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| UniProt accession | Q8WVM8 |
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| Gene | SCFD1 |
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| Organism | Homo sapiens |
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| Length | 642 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- body height · score 0.41
- amyotrophic lateral sclerosis · score 0.36
- mean corpuscular volume · score 0.32
- mean reticulocyte volume · score 0.29
- mathematical ability · score 0.28
- urinary bladder cancer · score 0.24
- event free survival time · score 0.24
- bone density · score 0.15
- urate measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WVM8-F1 | alphafold | PREDICTED | 84.58 | — |
Amino-acid sequence (642 residues)
MAAAAAATAA AAASIRERQT VALKRMLNFN VPHIKNSTGE PVWKVLIYDR FGQDIISPLL SVKELRDMGI TLHLLLHSDR DPIPDVPAVY FVMPTEENID RMCQDLRNQL YESYYLNFIS AISRSKLEDI ANAALAASAV TQVAKVFDQY LNFITLEDDM FVLCNQNKEL VSYRAINRPD ITDTEMETVM DTIVDSLFCF FVTLGAVPII RCSRGTAAEM VAVKLDKKLR ENLRDARNSL FTGDTLGAGQ FSFQRPLLVL VDRNIDLATP LHHTWTYQAL VHDVLDFHLN RVNLEESSGV ENSPAGARPK RKNKKSYDLT PVDKFWQKHK GSPFPEVAES VQQELESYRA QEDEVKRLKS IMGLEGEDEG AISMLSDNTA KLTSAVSSLP ELLEKKRLID LHTNVATAVL EHIKARKLDV YFEYEEKIMS KTTLDKSLLD IISDPDAGTP EDKMRLFLIY YISTQQAPSE ADLEQYKKAL TDAGCNLNPL QYIKQWKAFT KMASAPASYG STTTKPMGLL SRVMNTGSQF VMEGVKNLVL KQQNLPVTRI LDNLMEMKSN PETDDYRYFD PKMLRGNDSS VPRNKNPFQE AIVFVVGGGN YIEYQNLVDY IKGKQGKHIL YGCSELFNAT QFIKQLSQLG QK
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