About Trafficking protein particle complex subunit 14
Trafficking protein particle complex subunit 14 (TRAPPC14) is a protein
from Homo sapiens identified by UniProt accession
Q8WVR3, 580 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Trafficking protein particle complex subunit 14 |
|---|
| UniProt accession | Q8WVR3 |
|---|
| Gene | TRAPPC14 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 580 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (13)
Diseases linked to this target (Open Targets).
- autosomal recessive primary microcephaly · score 0.46
- diet measurement · score 0.07
- age at menarche · score 0.05
- hepatocellular carcinoma · score 0.04
- protein measurement · score 0.03
- mean corpuscular volume · score 0.02
- neoplasm · score 0.02
- hemoglobin measurement · score 0.02
- Microcephaly · score 0.02
- acute lymphoblastic leukemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WVR3-F1 | alphafold | PREDICTED | 70.17 | — |
Amino-acid sequence (580 residues)
MESQCDYSMY FPAVPLPPRA ELAGDPGRYR ALPRRNHLYL GETVRFLLVL RCRGGAGSGT GGGPGLGSRG AWAELATALA ALASVSAGGG MPGGGGAGDQ DSEPPGGGDP GGGGLFRGCS PLLTHGPGPA TSGGATTLPV EEPIVSTDEV IFPLTVSLDR LPPGTPKAKI VVTVWKREIE APEVRDQGYL RLLQTRSPGE TFRGEQSAFK AQVSTLLTLL PPPVLRCRQF TVAGKHLTVL KVLNSSSQEE ISIWDIRILP NFNASYLPVM PDGSVLLVDN VCHQSGEVSM GSFCRLPGTS GCFPCPLNAL EEHNFLFQLR GGEQPPPGAK EGLEVPLIAV VQWSTPKLPF TQSIYTHYRL PSVRLDRPCF VMTASCKSPV RTYERFTVTY TLLNNLQDFL AVRLVWTPEH AQAGKQLCEE ERRAMQAALD SVVCHTPLNN LGFSRKGSAL TFSVAFQALR TGLFELSQHM KLKLQFTASV SHPPPEARPL SRKSSPSSPA VRDLVERHQA SLGRSQSFSH QQPSRSHLMR SGSVMERRAI TPPVASPVGR PLYLPPDKAV LSLDKIAKRE CKVLVVEPVK
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