About Cytoplasmic dynein 2 intermediate chain 1
Cytoplasmic dynein 2 intermediate chain 1 (DYNC2I1) is a protein
from Homo sapiens identified by UniProt accession
Q8WVS4, 1066 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Cytoplasmic dynein 2 intermediate chain 1 |
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| UniProt accession | Q8WVS4 |
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| Gene | DYNC2I1 |
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| Organism | Homo sapiens |
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| Length | 1066 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- Short rib-polydactyly syndrome, Verma-Naumoff type · score 0.70
- Jeune syndrome · score 0.51
- asphyxiating thoracic dystrophy 3 · score 0.47
- short rib-polydactyly syndrome, Majewski type · score 0.47
- mean platelet volume · score 0.25
- adolescent idiopathic scoliosis · score 0.20
- genetic disorder · score 0.19
- platelet count · score 0.07
- gastric cancer · score 0.05
- refractive error · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WVS4-F1 | alphafold | PREDICTED | 63.46 | — |
Amino-acid sequence (1066 residues)
MEPGKRRTKD DTWKADDLRK HLWAIQSGGS KEERKHREKK LRKESEMDLP EHKEPRCRDP DQDARSRDRV AEVHTAKESP RGERDRDRQR ERRRDAKDRE KEKLKEKHRE AEKSHSRGKD REKEKDRRAR KEELRQTVAH HNLLGQETRD RQLLERAERK GRSVSKVRSE EKDEDSERGD EDRERRYRER KLQYGDSKDN PLKYWLYKEE GERRHRKPRE PDRDNKHREK SSTREKREKY SKEKSNSFSD KGEERHKEKR HKEGFHFDDE RHQSNVDRKE KSAKDEPRKR ESQNGEHRNR GASSKRDGTS SQHAENLVRN HGKDKDSRRK HGHEEGSSVW WKLDQRPGGE ETVEIEKEET DLENARADAY TASCEDDFED YEDDFEVCDG DDDESSNEPE SREKLEELPL AQKKEIQEIQ RAINAENERI GELSLKLFQK RGRTEFEKEP RTDTNSSPSR ASVCGIFVDF ASASHRQKSR TQALKQKMRS TKLLRLIDLD FSFTFSLLDL PPVNEYDMYI RNFGKKNTKQ AYVQCNEDNV ERDIQTEEIE TREVWTQHPG ESTVVSGGSE QRDTSDAVVM PKIDTPRLCS FLRAACQVMA VLLEEDRLAA EPSWNLRAQD RALYFSDSSS QLNTSLPFLQ NRKVSSLHTS RVQRQMVVSV HDLPEKSFVP LLDSKYVLCV WDIWQPSGPQ KVLICESQVT CCCLSPLKAF LLFAGTAHGS VVVWDLREDS RLHYSVTLSD GFWTFRTATF STDGILTSVN HRSPLQAVEP ISTSVHKKQS FVLSPFSTQE EMSGLSFHIA SLDESGVLNV WVVVELPKAD IAGSISDLGL MPGGRVKLVH SALIQLGDSL SHKGNEFWGT TQTLNVKFLP SDPNHFIIGT DMGLISHGTR QDLRVAPKLF KPQQHGIRPV KVNVIDFSPF GEPIFLAGCS DGSIRLHQLS SAFPLLQWDS STDSHAVTGL QWSPTRPAVF LVQDDTSNIY IWDLLQSDLG PVAKQQVSPN RLVAMAAVGE PEKAGGSFLA LVLARASGSI DIQHLKRRWA APEVDECNRL RLLLQEALWP EGKLHK
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