About Trafficking protein particle complex subunit 12
Trafficking protein particle complex subunit 12 (TRAPPC12) is a protein
from Homo sapiens identified by UniProt accession
Q8WVT3, 735 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Trafficking protein particle complex subunit 12 |
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| UniProt accession | Q8WVT3 |
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| Gene | TRAPPC12 |
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| Organism | Homo sapiens |
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| Length | 735 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- early-onset progressive encephalopathy-hearing loss-pons hypoplasia-brain atrophy syndrome · score 0.77
- neurodegenerative disease · score 0.52
- genetic disorder · score 0.50
- Hydrocephalus · score 0.37
- Severe hydrocephalus · score 0.26
- brain measurement · score 0.25
- Abnormality of refraction · score 0.12
- PHF-tau measurement · score 0.08
- protein measurement · score 0.08
- Lobular Breast Carcinoma In Situ · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WVT3-F1 | alphafold | PREDICTED | 66.93 | — |
Amino-acid sequence (735 residues)
MEDAGGGEET PAPEAPHPPQ LAPPEEQGLL FQEETIDLGG DEFGSEENET ASEGSSPLAD KLNEHMMESV LISDSPNSEG DAGDLGRVRD EAEPGGEGDP GPEPAGTPSP SGEADGDCAP EDAAPSSGGA PRQDAAREVP GSEAARPEQE PPVAEPVPVC TIFSQRAPPA SGDGFEPQMV KSPSFGGASE ASARTPPQVV QPSPSLSTFF GDTAASHSLA SDFFDSFTTS AFISVSNPGA GSPAPASPPP LAVPGTEGRP EPVAMRGPQA AAPPASPEPF AHIQAVFAGS DDPFATALSM SEMDRRNDAW LPGEATRGVL RAVATQQRGA VFVDKENLTM PGLRFDNIQG DAVKDLMLRF LGEKAAAKRQ VLNADSVEQS FVGLKQLISC RNWRAAVDLC GRLLTAHGQG YGKSGLLTSH TTDSLQLWFV RLALLVKLGL FQNAEMEFEP FGNLDQPDLY YEYYPHVYPG RRGSMVPFSM RILHAELQQY LGNPQESLDR LHKVKTVCSK ILANLEQGLA EDGGMSSVTQ EGRQASIRLW RSRLGRVMYS MANCLLLMKD YVLAVEAYHS VIKYYPEQEP QLLSGIGRIS LQIGDIKTAE KYFQDVEKVT QKLDGLQGKI MVLMNSAFLH LGQNNFAEAH RFFTEILRMD PRNAVANNNA AVCLLYLGKL KDSLRQLEAM VQQDPRHYLH ESVLFNLTTM YELESSRSMQ KKQALLEAVA GKEGDSFNTQ CLKLA
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