About tRNA-splicing endonuclease subunit Sen15
tRNA-splicing endonuclease subunit Sen15 (TSEN15) is a protein
from Homo sapiens identified by UniProt accession
Q8WW01, 171 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | tRNA-splicing endonuclease subunit Sen15 |
|---|
| UniProt accession | Q8WW01 |
|---|
| Gene | TSEN15 |
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| Organism | Homo sapiens |
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| Length | 171 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (48)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 2 · score 0.60
- body height · score 0.34
- BMI-adjusted waist circumference · score 0.33
- lean body mass · score 0.30
- smoking behavior · score 0.29
- osteoarthritis, hip · score 0.28
- physical activity measurement · score 0.28
- body fat distribution · score 0.28
- BMI-adjusted hip circumference · score 0.28
- sex hormone-binding globulin measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WW01-F1 | alphafold | PREDICTED | 77.05 | — |
Amino-acid sequence (171 residues)
MEERGDSEPT PGCSGLGPGG VRGFGDGGGA PSWAPEDAWM GTHPKYLEMM ELDIGDATQV YVAFLVYLDL MESKSWHEVN CVGLPELQLI CLVGTEIEGE GLQTVVPTPI TASLSHNRIR EILKASRKLQ GDPDLPMSFT LAIVESDSTI VYYKLTDGFM LPDPQNISLR R
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