About PEST proteolytic signal-containing nuclear protein
PEST proteolytic signal-containing nuclear protein (PCNP) is a protein
from Homo sapiens identified by UniProt accession
Q8WW12, 178 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | PEST proteolytic signal-containing nuclear protein |
|---|
| UniProt accession | Q8WW12 |
|---|
| Gene | PCNP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 178 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.28
- calcium measurement · score 0.24
- mean corpuscular volume · score 0.08
- body height · score 0.06
- body fat percentage · score 0.06
- serum gamma-glutamyl transferase measurement · score 0.06
- isolated spina bifida · score 0.05
- sex hormone-binding globulin measurement · score 0.05
- mean reticulocyte volume · score 0.05
- eosinophil count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WW12-F1 | alphafold | PREDICTED | 62.79 | — |
Amino-acid sequence (178 residues)
MADGKAGDEK PEKSQRAGAA GGPEEEAEKP VKTKTVSSSN GGESSSRSAE KRSAEEEAAD LPTKPTKISK FGFAIGSQTT KKASAISIKL GSSKPKETVP TLAPKTLSVA AAFNEDEDSE PEEMPPEAKM RMKNIGRDTP TSAGPNSFNK GKHGFSDNQK LWERNIKSHL GNVHDQDN
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