Tektin-4 (TEKT4)

About Tektin-4

Tektin-4 (TEKT4) is a protein from Homo sapiens identified by UniProt accession Q8WW24, 435 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	Tektin-4
UniProt accession	Q8WW24
Gene	TEKT4
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

glucuronate measurement · score 0.29
neurodegenerative disease · score 0.28
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
spermatogenic failure 72 · score 0.06
spermatogenic failure 27 · score 0.06
spermatogenic failure 46 · score 0.06
spermatogenic failure 18 · score 0.06
spermatogenic failure 65 · score 0.06
spermatogenic failure 43 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WW24-F1	alphafold	PREDICTED	91.07	—

Amino-acid sequence (435 residues)

MAQTVPPCEL PCKEYDVARN TGAYTSSGLA TASFRTSKYL LEEWFQNCYA RYHQAFADRD QSERQRHESQ QLATETQALA QRTQQDSTRT VGERLQDTHS WKSELQREME ALAAETNLLL AQKQRLERAL DATEVPFSIT TDNLQCRERR EHPNLVRDHV ETELLKEAEL IRNIQELLKR TIMQAVSQIR LNREHKETCE MDWSDKMEAY NIDETCGRHH SQSTEVQAHP YSTTFQESAS TPETRAKFTQ DNLCRAQRER LASANLRVLV DCILRDTSED LRLQCDAVNL AFGRRCEELE DARYKLHHHL HKTLREITDQ EHNVAALKQA IKDKEAPLHV AQTRLYLRSH RPNMELCRDA AQFRLLSEVE ELNMSLTALR EKLLEAEQSL RNLEDIHMSL EKDIAAMTNS LFIDRQKCMA HRTRYPTILQ LAGYQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards