Putative deaminase APOBEC-4 (APOBEC4)

About Putative deaminase APOBEC-4

Putative deaminase APOBEC-4 (APOBEC4) is a protein from Homo sapiens identified by UniProt accession Q8WW27, 367 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Putative deaminase APOBEC-4
UniProt accession	Q8WW27
Gene	APOBEC4
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
aspartate aminotransferase measurement · score 0.11
aspartate aminotransferase to alanine aminotransferase ratio · score 0.07
chronotype measurement · score 0.04
type 1 diabetes mellitus · score 0.04
systemic lupus erythematosus · score 0.02
squamous cell carcinoma · score 0.01
lung adenocarcinoma · score 0.01
myelodysplastic syndrome · score 0.00
endometrial carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WW27-F1	alphafold	PREDICTED	71.44	—

Amino-acid sequence (367 residues)

MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ IFGFPYGTTF PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE MNGYLDSAIY NNDSIRHIIL YSNNSPCNEA NHCCISKMYN FLITYPGITL SIYFSQLYHT EMDFPASAWN REALRSLASL WPRVVLSPIS GGIWHSVLHS FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT DVLLQTKRNP NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ FASSKEADEK KKKKGKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards