About High mobility group protein B4
High mobility group protein B4 (HMGB4) is a protein
from Homo sapiens identified by UniProt accession
Q8WW32, 186 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | High mobility group protein B4 |
|---|
| UniProt accession | Q8WW32 |
|---|
| Gene | HMGB4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 186 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- body fat percentage · score 0.18
- glucuronate measurement · score 0.18
- age at first facial hair · score 0.12
- gut microbiome measurement · score 0.11
- PHF-tau measurement · score 0.07
- protein measurement · score 0.06
- base metabolic rate measurement · score 0.02
- neurofibrillary tangles measurement · score 0.02
- Lentivirus Infections · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WW32-F1 | alphafold | PREDICTED | 88.21 | — |
Amino-acid sequence (186 residues)
MGKEIQLKPK ANVSSYVHFL LNYRNKFKEQ QPNTYVGFKE FSRKCSEKWR SISKHEKAKY EALAKLDKAR YQEEMMNYVG KRKKRRKRDP QEPRRPPSSF LLFCQDHYAQ LKRENPNWSV VQVAKATGKM WSTATDLEKH PYEQRVALLR AKYFEELELY RKQCNARKKY RMSARNRCRG KRVRQS
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