Dynein light chain Tctex-type protein 2B (DYNLT2B)

About Dynein light chain Tctex-type protein 2B

Dynein light chain Tctex-type protein 2B (DYNLT2B) is a protein from Homo sapiens identified by UniProt accession Q8WW35, 142 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Dynein light chain Tctex-type protein 2B
UniProt accession	Q8WW35
Gene	DYNLT2B
Organism	Homo sapiens
Length	142 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

short-rib thoracic dysplasia 17 with or without polydactyly · score 0.58
short rib-polydactyly syndrome, Majewski type · score 0.33
Short rib-polydactyly syndrome, Verma-Naumoff type · score 0.33
asphyxiating thoracic dystrophy 3 · score 0.33
C-reactive protein measurement · score 0.12
lean body mass · score 0.09
azoospermia · score 0.09
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WW35-F1	alphafold	PREDICTED	85.80	—

Amino-acid sequence (142 residues)

MATSIGVSFS VGDGVPEAEK NAGEPENTYI LRPVFQQRFR PSVVKDCIHA VLKEELANAE YSPEEMPQLT KHLSENIKDK LKEMGFDRYK MVVQVVIGEQ RGEGVFMASR CFWDADTDNY THDVFMNDSL FCVVAAFGCF YY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards