Gamma-secretase subunit APH-1B (APH1B)

About Gamma-secretase subunit APH-1B

Gamma-secretase subunit APH-1B (APH1B) is a protein from Homo sapiens identified by UniProt accession Q8WW43, 257 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Gamma-secretase subunit APH-1B
UniProt accession	Q8WW43
Gene	APH1B
Organism	Homo sapiens
Length	257 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WW43-F1	alphafold	PREDICTED	90.73	—

Amino-acid sequence (257 residues)

MTAAVFFGCA FIAFGPALAL YVFTIATEPL RIIFLIAGAF FWLVSLLISS LVWFMARVII DNKDGPTQKY LLIFGAFVSV YIQEMFRFAY YKLLKKASEG LKSINPGETA PSMRLLAYVS GLGFGIMSGV FSFVNTLSDS LGPGTVGIHG DSPQFFLYSA FMTLVIILLH VFWGIVFFDG CEKKKWGILL IVLLTHLLVS AQTFISSYYG INLASAFIIL VLMGTWAFLA AGGSCRSLKL CLLCQDKNFL LYNQRSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards