Transmembrane emp24 domain-containing protein 6…

About Transmembrane emp24 domain-containing protein 6

Transmembrane emp24 domain-containing protein 6 (TMED6) is a protein from Homo sapiens identified by UniProt accession Q8WW62, 240 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Transmembrane emp24 domain-containing protein 6
UniProt accession	Q8WW62
Gene	TMED6
Organism	Homo sapiens
Length	240 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

high density lipoprotein cholesterol measurement · score 0.30
total cholesterol measurement · score 0.15
apolipoprotein A 1 measurement · score 0.15
pulse pressure measurement · score 0.07
body fat percentage · score 0.06
congenital disorder of glycosylation type I · score 0.05
Isolated polycystic liver disease · score 0.05
glycine N-methyltransferase deficiency · score 0.05
body height · score 0.05
body mass index · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WW62-F1	alphafold	PREDICTED	81.42	—

Amino-acid sequence (240 residues)

MSPLLFGAGL VVLNLVTSAR SQKTEPLSGS GDQPLFRGAD RYDFAIMIPP GGTECFWQFA HQTGYFYFSY EVQRTVGMSH DRHVAATAHN PQGFLIDTSQ GVRGQINFST QETGFYQLCL SNQHNHFGSV QVYLNFGVFY EGPETDHKQK ERKQLNDTLD AIEDGTQKVQ NNIFHMWRYY NFARMRKMAD FFLIQSNYNY VNWWSTAQSL VIILSGILQL YFLKRLFNVP TTTDTKKPRC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Transmembrane emp24 domain-containing protein 6 (TMED6)