About Transmembrane protein 40
Transmembrane protein 40 (TMEM40) is a protein
from Homo sapiens identified by UniProt accession
Q8WWA1, 233 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Transmembrane protein 40 |
|---|
| UniProt accession | Q8WWA1 |
|---|
| Gene | TMEM40 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 233 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- left ventricular ejection fraction measurement · score 0.27
- P wave duration · score 0.14
- Noonan syndrome with multiple lentigines · score 0.12
- Noonan syndrome · score 0.12
- sex hormone-binding globulin measurement · score 0.11
- calf circumference measurement · score 0.07
- nonpapillary renal cell carcinoma · score 0.07
- platelet count · score 0.07
- neoplasm · score 0.05
- hemoglobin measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WWA1-F1 | alphafold | PREDICTED | 50.71 | — |
Amino-acid sequence (233 residues)
METSASSSQP QDNSQVHRET EDVDYGETDF HKQDGKAGLF SQEQYERNKS SSSSSSSSSS SSSSSSSSSS ESNDEDQQPR ATGKHRRSLG AGYPHGNGSP GPGHGEPDVL KDELQLYGDA PGEVVPSGES GLRRRGSDPA SGEVEASQLR RLNIKKDDEF FHFVLLCFAI GALLVCYHYY ADWFMSLGVG LLTFASLETV GIYFGLVYRI HSVLQGFIPL FQKFRLTGFR KTD
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