PIH1 domain-containing protein 2 (PIH1D2)

About PIH1 domain-containing protein 2

PIH1 domain-containing protein 2 (PIH1D2) is a protein from Homo sapiens identified by UniProt accession Q8WWB5, 315 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	PIH1 domain-containing protein 2
UniProt accession	Q8WWB5
Gene	PIH1D2
Organism	Homo sapiens
Length	315 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

serum gamma-glutamyl transferase measurement · score 0.11
risk-taking behaviour · score 0.09
bone quantitative ultrasound measurement · score 0.07
heel bone mineral density · score 0.06
waist-hip ratio · score 0.05
bone density · score 0.05
protein measurement · score 0.05
interleukin 18 measurement · score 0.02
triglyceride measurement · score 0.02
high density lipoprotein cholesterol measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWB5-F1	alphafold	PREDICTED	77.95	—

Amino-acid sequence (315 residues)

METSSKGLLT QVTQFWNLLD DLAQSDPEGY EKFIQQQLKE GKQLCAAPEP QLCLQTRILK PKEKILFINL CQWTRIPAPQ STTHPVPLTV GKPEDTTEIS DAYTVIDVAY NPDVLHAAEK DQVKKNQLIQ MAMKCIEEKF QFTLSHSYHI TKFRIKGSIQ RMKQNLMGIQ TDSIDLREKM RRELTLGQIR SSTMSNPDHF PQLLLPKDQV SGKAVCLIEE ISSTEIQVEM KMPAYELKIV HDHSEKPLKI ELKVELPGIN SVSLCDLSVS EDDLLIEVSE KYRLHLNLPK LIDTEMTTAK FIKEKSTLII TMPLV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards