About m-AAA protease-interacting protein 1, mitochondrial
m-AAA protease-interacting protein 1, mitochondrial (MAIP1) is a protein
from Homo sapiens identified by UniProt accession
Q8WWC4, 291 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | m-AAA protease-interacting protein 1, mitochondrial |
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| UniProt accession | Q8WWC4 |
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| Gene | MAIP1 |
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| Organism | Homo sapiens |
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| Length | 291 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- smoking status measurement · score 0.34
- body height · score 0.27
- smoking initiation · score 0.26
- LDL cholesterol:HDL cholesterol ratio · score 0.23
- ventricular tachycardia · score 0.23
- Red cell distribution width · score 0.21
- schizophrenia · score 0.19
- health study participation · score 0.19
- sleep duration · score 0.18
- physical activity · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WWC4-F1 | alphafold | PREDICTED | 66.99 | — |
Amino-acid sequence (291 residues)
MALAARLLPQ FLHSRSLPCG AVRLRTPAVA EVRLPSATLC YFCRCRLGLG AALFPRSARA LAASALPAQG SRWPVLSSPG LPAAFASFPA CPQRSYSTEE KPQQHQKTKM IVLGFSNPIN WVRTRIKAFL IWAYFDKEFS ITEFSEGAKQ AFAHVSKLLS QCKFDLLEEL VAKEVLHALK EKVTSLPDNH KNALAANIDE IVFTSTGDIS IYYDEKGRKF VNILMCFWYL TSANIPSETL RGASVFQVKL GNQNVETKQL LSASYEFQRE FTQGVKPDWT IARIEHSKLL E
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