Serine-rich single-pass membrane protein 1 (SSMEM1)

About Serine-rich single-pass membrane protein 1

Serine-rich single-pass membrane protein 1 (SSMEM1) is a protein from Homo sapiens identified by UniProt accession Q8WWF3, 244 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Serine-rich single-pass membrane protein 1
UniProt accession	Q8WWF3
Gene	SSMEM1
Organism	Homo sapiens
Length	244 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.22
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.07
spermatogenic failure 42 · score 0.07
spermatogenic failure 72 · score 0.06
spermatogenic failure 65 · score 0.06
spermatogenic failure 46 · score 0.06
spermatogenic failure 18 · score 0.06
spermatogenic failure 27 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWF3-F1	alphafold	PREDICTED	57.77	—

Amino-acid sequence (244 residues)

MGDLFSLFWE VDPPPIPVNC AIPNQDYECW KDDSCGTIGS FLLWYFVIVF VLMFFSRASV WMSEDKKDEG SGTSTSVRKA SKETSCKRQS KDSAWDPSQT MKKPKQNQLT PVTNSEVALV NAYPEQRRAR RQSQFNEVNQ NQHDSDTTEY GSEESNSEAS SWKESESEHH PSPDSIKRRK MAQRQRNLGS YQMSERHCLH CKALRTNEWL AHHSRQKPSV TPPMKRDSQE ESSISDINKK FSKF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards