E3 ubiquitin-protein ligase ZNRF4 (ZNRF4)

About E3 ubiquitin-protein ligase ZNRF4

E3 ubiquitin-protein ligase ZNRF4 (ZNRF4) is a protein from Homo sapiens identified by UniProt accession Q8WWF5, 429 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase ZNRF4
UniProt accession	Q8WWF5
Gene	ZNRF4
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (7)

Diseases linked to this target (Open Targets).

visual perception measurement · score 0.20
metabolite measurement · score 0.15
DNA methylation · score 0.07
mitochondrial DNA measurement · score 0.02
listeriosis · score 0.01
bacterial disease · score 0.01
breast cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWF5-F1	alphafold	PREDICTED	66.37	—

Amino-acid sequence (429 residues)

MPLCRPEHLM PRASRVPVAA SLPLSHAVIP TQLPSRPGHR PPGRPRRCPK ASCLPPPVGP SSTQTAKRVT MGWPRPGRAL VAVKALLVLS LLQVPAQAVV RAVLEDNSSS VDFADLPALF GVPLAPEGIR GYLMEVKPAN ACHPIEAPRL GNRSLGAIVL IRRYDCTFDL KVLNAQRAGF EAAIVHNVHS DDLVSMTHVY EDLRGQIAIP SVFVSEAASQ DLRVILGCNK SAHALLLPDD PPCHDLGCHP VLTVSWVLGC TLALVVSAFF VLNHLWLWAQ ACCSHRRPVK TSTCQKAQVR TFTWHNDLCA ICLDEYEEGD QLKILPCSHT YHCKCIDPWF SQAPRRSCPV CKQSVAATED SFDSTTYSFR DEDPSLPGHR PPIWAIQVQL RSRRLELLGR ASPHCHCSTT SLEAEYTTVS SAPPEAPGQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards