Pro-neuregulin-4, membrane-bound isoform (NRG4)

About Pro-neuregulin-4, membrane-bound isoform

Pro-neuregulin-4, membrane-bound isoform (NRG4) is a protein from Homo sapiens identified by UniProt accession Q8WWG1, 115 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.

Target properties

Protein name	Pro-neuregulin-4, membrane-bound isoform
UniProt accession	Q8WWG1
Gene	NRG4
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (118)

Diseases linked to this target (Open Targets).

cancer · score 0.58
hematocrit · score 0.46
hemoglobin measurement · score 0.46
erythrocyte count · score 0.44
urate measurement · score 0.44
glomerular filtration rate · score 0.44
creatinine measurement · score 0.42
uric acid measurement · score 0.37
mean corpuscular hemoglobin concentration · score 0.37
serum urea measurement · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWG1-F1	alphafold	PREDICTED	77.95	—

Amino-acid sequence (115 residues)

MPTDHEEPCG PSHKSFCLNG GLCYVIPTIP SPFCRCVENY TGARCEEVFL PGSSIQTKSN LFEAFVALAV LVTLIIGAFY FLCRKGHFQR ASSVQYDINL VETSSTSAHH SHEQH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards