Potassium voltage-gated channel subfamily E member…

About Potassium voltage-gated channel subfamily E member 4

Potassium voltage-gated channel subfamily E member 4 (KCNE4) is a protein from Homo sapiens identified by UniProt accession Q8WWG9, 221 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	Potassium voltage-gated channel subfamily E member 4
UniProt accession	Q8WWG9
Gene	KCNE4
Organism	Homo sapiens
Length	221 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.49
lymphocyte count · score 0.48
lean body mass · score 0.47
mean corpuscular volume · score 0.44
reticulocyte count · score 0.44
body height · score 0.44
appendicular lean mass · score 0.43
platelet component distribution width · score 0.43
lymphocyte percentage of leukocytes · score 0.40
neutrophil percentage of leukocytes · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWG9-F1	alphafold	PREDICTED	56.97	—

Amino-acid sequence (221 residues)

MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA SMLKMEPLNS THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF LIGIMLGYMK SKRREKKSSL LLLYKDEERL WGEAMKPLPV VSGLRSVQVP LMLNMLQESV APALSCTLCS MEGDSVSSES SSPDVHLTIQ EEGADDELEE TSETPLNESS EGSSENIHQN S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Potassium voltage-gated channel subfamily E member 4 (KCNE4)