Pseudouridylate synthase TRUB1 (TRUB1)

About Pseudouridylate synthase TRUB1

Pseudouridylate synthase TRUB1 (TRUB1) is a protein from Homo sapiens identified by UniProt accession Q8WWH5, 349 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Pseudouridylate synthase TRUB1
UniProt accession	Q8WWH5
Gene	TRUB1
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

Abnormality of refraction · score 0.29
dehydrated hereditary stomatocytosis · score 0.05
PHF-tau measurement · score 0.05
hemoglobin E-beta-thalassemia syndrome · score 0.05
Adult-onset autosomal recessive sideroblastic anemia · score 0.05
hemolytic anemia due to erythrocyte adenosine deaminase overproduction · score 0.05
gluthathione peroxidase deficiency · score 0.04
IRIDA syndrome · score 0.04
Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
Rh deficiency syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWH5-F1	alphafold	PREDICTED	81.10	—

Amino-acid sequence (349 residues)

MAASEAAVVS SPSLKTDTSP VLETAGTVAA MAATPSARAA AAVVAAAART GSEARVSKAA LATKLLSLSG VFAVHKPKGP TSAELLNRLK EKLLAEAGMP SPEWTKRKKQ TLKIGHGGTL DSAARGVLVV GIGSGTKMLT SMLSGSKRYT AIGELGKATD TLDSTGRVTE EKPYDKITQE DIEGILQKFT GNIMQVPPLY SALKKDGQRL STLMKRGEVV EAKPARPVTV YSISLQKFQP PFFTLDVECG GGFYIRSLVS DIGKELSSCA NVLELTRTKQ GPFTLEEHAL PEDKWTIDDI AQSLEHCSSL FPAELALKKS KPESNEQVLS CEYITLNEPK REDDVIKTC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards