About Choline transporter-like protein 1
Choline transporter-like protein 1 (SLC44A1) is a protein
from Homo sapiens identified by UniProt accession
Q8WWI5, 657 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Choline transporter-like protein 1 |
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| UniProt accession | Q8WWI5 |
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| Gene | SLC44A1 |
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| Organism | Homo sapiens |
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| Length | 657 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (100)
Diseases linked to this target (Open Targets).
- neurodegeneration, childhood-onset, with ataxia, tremor, optic atrophy, and cognitive decline · score 0.64
- BMI-adjusted waist-hip ratio · score 0.36
- waist-hip ratio · score 0.29
- triglyceride measurement · score 0.28
- Neurodevelopmental disorder · score 0.27
- BMI-adjusted waist circumference · score 0.26
- glioblastoma multiforme · score 0.19
- breast adenocarcinoma · score 0.18
- PHF-tau measurement · score 0.16
- cutaneous melanoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WWI5-F1 | alphafold | PREDICTED | 83.35 | — |
Amino-acid sequence (657 residues)
MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI ATGAAARLVS GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL DLINRKIKSV ALCVAACPRQ ELKTLSDVQK FAEINGSALC SYNLKPSEYT TSPKSSVLCP KLPVPASAPI PFFHRCAPVN ISCYAKFAEA LITFVSDNSV LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL VWILTILVIL GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV YWIMTLLFLG TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL ACQQMTVAGA VVTYYFTRDK RNLPFTPILA SVNRLIRYHL GTVAKGSFII TLVKIPRMIL MYIHSQLKGK ENACARCVLK SCICCLWCLE KCLNYLNQNA YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML FLGKVLIVCS TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM ASGASSA
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