About Cytoskeleton-associated protein 2
Cytoskeleton-associated protein 2 (CKAP2) is a protein
from Homo sapiens identified by UniProt accession
Q8WWK9, 683 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Cytoskeleton-associated protein 2 |
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| UniProt accession | Q8WWK9 |
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| Gene | CKAP2 |
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| Organism | Homo sapiens |
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| Length | 683 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (76)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.11
- hepatocellular carcinoma · score 0.08
- breast cancer · score 0.08
- cervical carcinoma · score 0.07
- adult-onset autosomal dominant demyelinating leukodystrophy · score 0.07
- neoplasm · score 0.05
- cancer · score 0.04
- colorectal cancer · score 0.03
- triple-negative breast cancer · score 0.03
- infection · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WWK9-F1 | alphafold | PREDICTED | 58.80 | — |
Amino-acid sequence (683 residues)
MSTPAVPQDL QLPPSQRAQS AFKEQRRQKL KEHLLRRKTL FAYKQENEML SSSRDQRVVT SEDQVQEGTK VLKLKTKMAD KENMKRPAES KNNTVVGKHC IPLKPSNELT NSTVVIDTHK PKDSNQTPHL LLTEDDPQSQ HMTLSQAFHL KNNSKKKQMT TEKQKQDANM PKKPVLGSYR GQIVQSKINS FRKPLQVKDE SSAATKKLSA TIPKATKPQP VNTSSVTVKS NRSSNMTATT KFVSTTSQNT QLVRPPIRSH HSNTRDTVKQ GISRTSANVT IRKGPHEKEL LQSKTALSSV KTSSSQGIIR NKTLSRSIAS EVIARPASLS NDKLMEKSEP VDQRRHTAGK AIVDSRSAQP KETSEERKAR LSEWKAGKGR VLKRPPNSVV TQHEPAGQNE KPVGSFWTTM AEEDEQRLFT EKVNNTFSEC LNLINEGCPK EDILVTLNDL IKNIPDAKKL VKYWICLALI EPITSPIENI IAIYEKAILA GAQPIEEMRH TIVDILTMKS QEKANLGENM EKSCASKEEV KEVSIEDTGV DVDPEKLEME SKLHRNLLFQ DCEKEQDNKT KDPTHDVKTP NTETRTSCLI KYNVSTTPYL QSVKKKVQFD GTNSAFKELK FLTPVRRSRR LQEKTSKLPD MLKDHYPCVS SLEQLTELGR ETDAFVCRPN AALCRVYYEA DTT
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