GTPase IMAP family member 1 (GIMAP1)

About GTPase IMAP family member 1

GTPase IMAP family member 1 (GIMAP1) is a protein from Homo sapiens identified by UniProt accession Q8WWP7, 306 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.

Target properties

Protein name	GTPase IMAP family member 1
UniProt accession	Q8WWP7
Gene	GIMAP1
Organism	Homo sapiens
Length	306 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (130)

Diseases linked to this target (Open Targets).

common variable immunodeficiency · score 0.07
isolated agammaglobulinemia · score 0.06
combined immunodeficiency with skin granulomas · score 0.06
classic Hodgkin lymphoma · score 0.06
Hodgkins lymphoma · score 0.06
immunodeficiency 18 · score 0.05
severe combined immunodeficiency due to CARD11 deficiency · score 0.05
severe combined immunodeficiency due to CTPS1 deficiency · score 0.05
Waldenstrom macroglobulinemia · score 0.05
BENTA disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWP7-F1	alphafold	PREDICTED	87.08	—

Amino-acid sequence (306 residues)

MGGRKMATDE ENVYGLEENA QSRQESTRRL ILVGRTGAGK SATGNSILGQ RRFFSRLGAT SVTRACTTGS RRWDKCHVEV VDTPDIFSSQ VSKTDPGCEE RGHCYLLSAP GPHALLLVTQ LGRFTAQDQQ AVRQVRDMFG EDVLKWMVIV FTRKEDLAGG SLHDYVSNTE NRALRELVAE CGGRVCAFDN RATGREQEAQ VEQLLGMVEG LVLEHKGAHY SNEVYELAQV LRWAGPEERL RRVAERVAAR VQRRPWGAWL SARLWKWLKS PRSWRLGLAL LLGGALLFWV LLHRRWSEAV AEVGPD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards