T-complex protein 11 homolog (TCP11)

About T-complex protein 11 homolog

T-complex protein 11 homolog (TCP11) is a protein from Homo sapiens identified by UniProt accession Q8WWU5, 503 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	T-complex protein 11 homolog
UniProt accession	Q8WWU5
Gene	TCP11
Organism	Homo sapiens
Length	503 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

body height · score 0.34
smoking cessation · score 0.28
wheezing · score 0.28
FEV/FVC ratio · score 0.26
C-reactive protein measurement · score 0.25
vital capacity · score 0.22
eosinophil percentage of leukocytes · score 0.21
osteoarthritis, knee · score 0.19
total joint arthroplasty · score 0.19
osteoarthritis, hip · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWU5-F1	alphafold	PREDICTED	77.66	—

Amino-acid sequence (503 residues)

MPDVKESVPP KYPGDSEGRS CKPETSGPPQ EDKSGSEDPP PFLSVTGLTE TVNEVSKLSN KIGMNCDYYM EEKVLPPSSL EGKVKETVHN AFWDHLKEQL SATPPDFSCA LELLKEIKEI LLSLLLPRQN RLRIEIEEAL DMDLLKQEAE HGALKVLYLS KYVLNMMALL CAPVRDEAVQ KLENITDPVW LLRGIFQVLG RMKMDMVNYT IQSLQPHLQE HSIQYERAKF QELLNKQPSL LNHTTKWLTQ AAGDLTMSPP TCPDTSDSSS VAGPSPNEAA NNPEPLSPTM VLCQGFLNLL LWDLENEEFP ETLLMDRTRL QELKSQLHQL TVMASVLLVA SSFSGSVLFG SPQFVDKLKR ITKSLLEDFH SRPEEAILTV SEQVSQEIHQ SLKNMGLVAL SSDNTASLMG QLQNIAKKEN CVCSVIDQRI HLFLKCCLVL GVQRSLLDLP GGLTLIEAEL AELGQKFVNL THHNQQVFGP YYTEILKTLI SPAQALETKV ESV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards