About High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (FCAMR) is a protein
from Homo sapiens identified by UniProt accession
Q8WWV6, 532 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor |
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| UniProt accession | Q8WWV6 |
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| Gene | FCAMR |
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| Organism | Homo sapiens |
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| Length | 532 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- lymphocyte count · score 0.13
- head and neck squamous cell carcinoma · score 0.11
- hyper-IgM syndrome type 3 · score 0.06
- hyper-IgM syndrome type 2 · score 0.05
- hyper-IgM syndrome type 5 · score 0.05
- autoimmune lymphoproliferative syndrome type 2B · score 0.05
- BENTA disease · score 0.05
- common variable immunodeficiency · score 0.05
- immunodeficiency, common variable, 14 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WWV6-F1 | alphafold | PREDICTED | 55.27 | — |
Amino-acid sequence (532 residues)
MPLFLILCLL QGSSFALPQK RPHPRWLWEG SLPSRTHLRA MGTLRPSSPL CWREESSFAA PNSLKGSRLV SGEPGGAVTI QCHYAPSSVN RHQRKYWCRL GPPRWICQTI VSTNQYTHHR YRDRVALTDF PQRGLFVVRL SQLSPDDIGC YLCGIGSENN MLFLSMNLTI SAGPASTLPT ATPAAGELTM RSYGTASPVA NRWTPGTTQT LGQGTAWDTV ASTPGTSKTT ASAEGRRTPG ATRPAAPGTG SWAEGSVKAP APIPESPPSK SRSMSNTTEG VWEGTRSSVT NRARASKDRR EMTTTKADRP REDIEGVRIA LDAAKKVLGT IGPPALVSET LAWEILPQAT PVSKQQSQGS IGETTPAAGM WTLGTPAADV WILGTPAADV WTSMEAASGE GSAAGDLDAA TGDRGPQATL SQTPAVGPWG PPGKESSVKR TFPEDESSSR TLAPVSTMLA LFMLMALVLL QRKLWRRRTS QEAERVTLIQ MTHFLEVNPQ ADQLPHVERK MLQDDSLPAG ASLTAPERNP GP
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