About GRB2-associated-binding protein 3
GRB2-associated-binding protein 3 (GAB3) is a protein
from Homo sapiens identified by UniProt accession
Q8WWW8, 586 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | GRB2-associated-binding protein 3 |
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| UniProt accession | Q8WWW8 |
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| Gene | GAB3 |
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| Organism | Homo sapiens |
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| Length | 586 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (51)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.14
- immunodeficiency 18 · score 0.06
- agammaglobulinemia 7, autosomal recessive · score 0.05
- severe combined immunodeficiency due to CTPS1 deficiency · score 0.05
- immunodeficiency 105 · score 0.05
- reticular dysgenesis · score 0.05
- T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.05
- severe combined immunodeficiency due to IKK2 deficiency · score 0.05
- combined immunodeficiency with skin granulomas · score 0.05
- HbA1c measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WWW8-F1 | alphafold | PREDICTED | 54.22 | — |
Amino-acid sequence (586 residues)
MSAGDAVCTG WLVKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN KHSSKPIRVI DLSECAVWKH VGPSFVRKEF QNNFVFIVKT TSRTFYLVAK TEQEMQVWVH SISQVCNLGH LEDGADSMES LSYTPSSLQP SSASSLLTAH AASSSLPRDD PNTNAVATEE TRSESELLFL PDYLVLSNCE TGRLHHTSLP TRCDSWSNSD RSLEQASFDD VFVDCLQPLP SSHLVHPSCH GSGAQEVPSS RPQAALIWSR EINGPPRDHL SSSPLLESSL SSTIQVDKNQ GSLPCGAKEL DIMSNTPPPR PPKPSHLSER RQEEWSTHSG SKKPECTLVP RRISLSGLDN MRTWKADVEG QSLRHRDKRL SLNLPCRFSP MYPTASASIE DSYVPMSPQA GASGLGPHCS PDDYIPMNSG SISSPLPELP ANLEPPPVNR DLKPQRKSRP PPLDLRNLSI IREHASLTRT RTVPCSRTSF LSPERNGINS ARFFANPVSR EDEESYIEME EHRTASSLSS GALTWTKKFS LDYLALDFNS ASPAPMQQKL LLSEEQRVDY VQVDEQKTQA LQSTKQEWTD ERQSKV
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