About Sodium/myo-inositol cotransporter 2
Sodium/myo-inositol cotransporter 2 (SLC5A11) is a protein
from Homo sapiens identified by UniProt accession
Q8WWX8, 675 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Sodium/myo-inositol cotransporter 2 |
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| UniProt accession | Q8WWX8 |
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| Gene | SLC5A11 |
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| Organism | Homo sapiens |
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| Length | 675 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (95)
Diseases linked to this target (Open Targets).
- alcohol consumption measurement · score 0.31
- systolic blood pressure · score 0.27
- alcohol use disorder measurement · score 0.24
- appendicular lean mass · score 0.23
- body mass index · score 0.23
- lean body mass · score 0.23
- smoking initiation · score 0.22
- body fat percentage · score 0.20
- pulse pressure measurement · score 0.19
- smoking cessation · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WWX8-F1 | alphafold | PREDICTED | 81.80 | — |
Amino-acid sequence (675 residues)
MESGTSSPQP PQLDPLDAFP QKGLEPGDIA VLVLYFLFVL AVGLWSTVKT KRDTVKGYFL AGGDMVWWPV GASLFASNVG SGHFIGLAGS GAATGISVSA YELNGLFSVL MLAWIFLPIY IAGQVTTMPE YLRKRFGGIR IPIILAVLYL FIYIFTKISV DMYAGAIFIQ QSLHLDLYLA IVGLLAITAV YTVAGGLAAV IYTDALQTLI MLIGALTLMG YSFAAVGGME GLKEKYFLAL ASNRSENSSC GLPREDAFHI FRDPLTSDLP WPGVLFGMSI PSLWYWCTDQ VIVQRTLAAK NLSHAKGGAL MAAYLKVLPL FIMVFPGMVS RILFPDQVAC ADPEICQKIC SNPSGCSDIA YPKLVLELLP TGLRGLMMAV MVAALMSSLT SIFNSASTIF TMDLWNHLRP RASEKELMIV GRVFVLLLVL VSILWIPVVQ ASQGGQLFIY IQSISSYLQP PVAVVFIMGC FWKRTNEKGA FWGLISGLLL GLVRLVLDFI YVQPRCDQPD ERPVLVKSIH YLYFSMILST VTLITVSTVS WFTEPPSKEM VSHLTWFTRH DPVVQKEQAP PAAPLSLTLS QNGMPEASSS SSVQFEMVQE NTSKTHSCDM TPKQSKVVKA ILWLCGIQEK GKEELPARAE AIIVSLEENP LVKTLLDVNL IFCVSCAIFI WGYFA
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