About U4/U6 small nuclear ribonucleoprotein Prp31
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) is a protein
from Homo sapiens identified by UniProt accession
Q8WWY3, 499 residues long.
MolForge cross-references it against 0 known binders and
118 disease associations.
Target properties
| Protein name | U4/U6 small nuclear ribonucleoprotein Prp31 |
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| UniProt accession | Q8WWY3 |
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| Gene | PRPF31 |
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| Organism | Homo sapiens |
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| Length | 499 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (118)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.75
- Retinal dystrophy · score 0.55
- autosomal dominant retinitis pigmentosa · score 0.42
- genetic disorder · score 0.19
- neurodegenerative disease · score 0.16
- chronic lymphocytic leukemia · score 0.15
- Leber congenital amaurosis · score 0.13
- age-related macular degeneration · score 0.10
- blood protein measurement · score 0.10
- X-linked retinal dysplasia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WWY3-F1 | alphafold | PREDICTED | 77.35 | — |
Amino-acid sequence (499 residues)
MSLADELLAD LEEAAEEEEG GSYGEEEEEP AIEDVQEETQ LDLSGDSVKT IAKLWDSKMF AEIMMKIEEY ISKQAKASEV MGPVEAAPEY RVIVDANNLT VEIENELNII HKFIRDKYSK RFPELESLVP NALDYIRTVK ELGNSLDKCK NNENLQQILT NATIMVVSVT ASTTQGQQLS EEELERLEEA CDMALELNAS KHRIYEYVES RMSFIAPNLS IIIGASTAAK IMGVAGGLTN LSKMPACNIM LLGAQRKTLS GFSSTSVLPH TGYIYHSDIV QSLPPDLRRK AARLVAAKCT LAARVDSFHE STEGKVGYEL KDEIERKFDK WQEPPPVKQV KPLPAPLDGQ RKKRGGRRYR KMKERLGLTE IRKQANRMSF GEIEEDAYQE DLGFSLGHLG KSGSGRVRQT QVNEATKARI SKTLQRTLQK QSVVYGGKST IRDRSSGTAS SVAFTPLQGL EIVNPQAAEK KVAEANQKYF SSMAEFLKVK GEKSGLMST
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