WAP four-disulfide core domain protein 12 (WFDC12)

About WAP four-disulfide core domain protein 12

WAP four-disulfide core domain protein 12 (WFDC12) is a protein from Homo sapiens identified by UniProt accession Q8WWY7, 111 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	WAP four-disulfide core domain protein 12
UniProt accession	Q8WWY7
Gene	WFDC12
Organism	Homo sapiens
Length	111 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

bipolar disorder · score 0.27
mean platelet volume · score 0.10
blood protein measurement · score 0.08
psoriasis · score 0.07
platelet count · score 0.02
dysplasia · score 0.02
esophageal squamous cell carcinoma · score 0.02
rosacea · score 0.01
systemic inflammatory response syndrome · score 0.01
acute respiratory distress syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WWY7-F1	alphafold	PREDICTED	78.23	—

Amino-acid sequence (111 residues)

MGSSSFLVLM VSLVLVTLVA VEGVKEGIEK AGVCPADNVR CFKSDPPQCH TDQDCLGERK CCYLHCGFKC VIPVKELEEG GNKDEDVSRP YPEPGWEAKC PGSSSTRCPQ K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards