Secretogranin-3 (SCG3)

About Secretogranin-3

Secretogranin-3 (SCG3) is a protein from Homo sapiens identified by UniProt accession Q8WXD2, 468 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	Secretogranin-3
UniProt accession	Q8WXD2
Gene	SCG3
Organism	Homo sapiens
Length	468 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (104)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.25
blood protein measurement · score 0.21
body mass index · score 0.18
self reported educational attainment · score 0.17
cognitive function measurement · score 0.17
developmental and epileptic encephalopathy, 13 · score 0.12
developmental and epileptic encephalopathy · score 0.12
schizophrenia · score 0.11
fat body mass · score 0.10
body fat percentage · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WXD2-F1	alphafold	PREDICTED	59.13	—

Amino-acid sequence (468 residues)

MGFLGTGTWI LVLVLPIQAF PKPGGSQDKS LHNRELSAER PLNEQIAEAE EDKIKKTYPP ENKPGQSNYS FVDNLNLLKA ITEKEKIEKE RQSIRSSPLD NKLNVEDVDS TKNRKLIDDY DSTKSGLDHK FQDDPDGLHQ LDGTPLTAED IVHKIAARIY EENDRAVFDK IVSKLLNLGL ITESQAHTLE DEVAEVLQKL ISKEANNYEE DPNKPTSWTE NQAGKIPEKV TPMAAIQDGL AKGENDETVS NTLTLTNGLE RRTKTYSEDN FEELQYFPNF YALLKSIDSE KEAKEKETLI TIMKTLIDFV KMMVKYGTIS PEEGVSYLEN LDEMIALQTK NKLEKNATDN ISKLFPAPSE KSHEETDSTK EEAAKMEKEY GSLKDSTKDD NSNPGGKTDE PKGKTEAYLE AIRKNIEWLK KHDKKGNKED YDLSKMRDFI NKQADAYVEK GILDKEEAEA IKRIYSSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards