About Cationic amino acid transporter 3
Cationic amino acid transporter 3 (SLC7A3) is a protein
from Homo sapiens identified by UniProt accession
Q8WY07, 619 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Cationic amino acid transporter 3 |
|---|
| UniProt accession | Q8WY07 |
|---|
| Gene | SLC7A3 |
|---|
| Organism | Homo sapiens |
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| Length | 619 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- uterine fibroid · score 0.11
- glioblastoma · score 0.03
- neoplasm · score 0.02
- papillary thyroid carcinoma · score 0.02
- glioblastoma multiforme · score 0.02
- Pneumonia · score 0.01
- infection · score 0.01
- infect · score 0.01
- Autism · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WY07-F1 | alphafold | PREDICTED | 83.72 | — |
Amino-acid sequence (619 residues)
MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISKTLQG SIALHVPHVL AEYPDFFALG LVLLLTGLLA LGASESALVT KVFTGVNLLV LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL GSGGFVPFGF EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL GSMFPMPRVI YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL FKLTDLVDLM SIGTLLAYSL VSICVLILRY QPDQETKTGE EVELQEEAIT TESEKLTLWG LFFPLNSIPT PLSGQIVYVC SSLLAVLLTA LCLVLAQWSV PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK VPALPLLPLM SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR KSRAKTVDLD PGTLYVHSV
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