About Nanos homolog 1
Nanos homolog 1 (NANOS1) is a protein
from Homo sapiens identified by UniProt accession
Q8WY41, 292 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Nanos homolog 1 |
|---|
| UniProt accession | Q8WY41 |
|---|
| Gene | NANOS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 292 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.37
- male infertility with teratozoospermia due to single gene mutation · score 0.36
- keratoconus · score 0.11
- platelet crit · score 0.07
- Infertility · score 0.03
- carpal tunnel syndrome · score 0.02
- cancer · score 0.02
- Tetralogy of Fallot · score 0.02
- adrenal cortex carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WY41-F1 | alphafold | PREDICTED | 61.04 | — |
Amino-acid sequence (292 residues)
MEAFPWAPRS PRRGRAPPPM ALVPSARYVS APGPAHPQPF SSWNDYLGLA TLITKAVDGE PRFGCARGGN GGGGSPPSSS SSSCCSPHTG AGPGALGPAL GPPDYDEDDD DDSDEPGSRG RYLGSALELR ALELCAGPAE AGLLEERFAE LSPFAGRAAA VLLGCAPAAA AAATTTSEAT PREERAPAWA AEPRLHAASG AAAARLLKPE LQVCVFCRNN KEAMALYTTH ILKGPDGRVL CPVLRRYTCP LCGASGDNAH TIKYCPLSKV PPPPARPPPR SARDGPPGKK LR
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