E3 ubiquitin-protein ligase MYLIP (MYLIP)

About E3 ubiquitin-protein ligase MYLIP

E3 ubiquitin-protein ligase MYLIP (MYLIP) is a protein from Homo sapiens identified by UniProt accession Q8WY64, 445 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase MYLIP
UniProt accession	Q8WY64
Gene	MYLIP
Organism	Homo sapiens
Length	445 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (99)

Diseases linked to this target (Open Targets).

low density lipoprotein cholesterol measurement · score 0.53
total cholesterol measurement · score 0.50
apolipoprotein B measurement · score 0.44
Hypercholesterolemia · score 0.40
alcohol consumption measurement · score 0.40
alcohol drinking · score 0.40
HMG CoA reductase inhibitor use measurement · score 0.38
physical activity · score 0.32
response to statin · score 0.32
hyperlipidemia · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WY64-F1	alphafold	PREDICTED	85.76	—

Amino-acid sequence (445 residues)

MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS ALLAQTKFGD YNQNTAKYNY EELCAKELSS ATLNSIVAKH KELEGTSQAS AEYQVLQIVS AMENYGIEWH SVRDSEGQKL LIGVGPEGIS ICKDDFSPIN RIAYPVVQMA TQSGKNVYLT VTKESGNSIV LLFKMISTRA ASGLYRAITE THAFYRCDTV TSAVMMQYSR DLKGHLASLF LNENINLGKK YVFDIKRTSK EVYDHARRAL YNAGVVDLVS RNNQSPSHSP LKSSESSMNC SSCEGLSCQQ TRVLQEKLRK LKEAMLCMVC CEEEINSTFC PCGHTVCCES CAAQLQSCPV CRSRVEHVQH VYLPTHTSLL NLTVI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards