About Intraflagellar transport protein 81 homolog
Intraflagellar transport protein 81 homolog (IFT81) is a protein
from Homo sapiens identified by UniProt accession
Q8WYA0, 676 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Intraflagellar transport protein 81 homolog |
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| UniProt accession | Q8WYA0 |
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| Gene | IFT81 |
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| Organism | Homo sapiens |
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| Length | 676 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (94)
Diseases linked to this target (Open Targets).
- short rib dysplasia · score 0.67
- mean corpuscular hemoglobin · score 0.34
- Short stature · score 0.32
- low density lipoprotein cholesterol measurement · score 0.29
- short rib-polydactyly syndrome · score 0.26
- Jeune syndrome · score 0.26
- erythrocyte count · score 0.26
- uric acid measurement · score 0.20
- mean arterial pressure · score 0.20
- diastolic blood pressure · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WYA0-F1 | alphafold | PREDICTED | 83.13 | — |
Amino-acid sequence (676 residues)
MSDQIKFIMD SLNKEPFRKN YNLITFDSLE PMQLLQVLSD VLAEIDPKQL VDIREEMPEQ TAKRMLSLLG ILKYKPSGNA TDMSTFRQGL VIGSKPVIYP VLHWLLQRTN ELKKRAYLAR FLIKLEVPSE FLQDETVADT NKQYEELMEA FKTLHKEYEQ LKISGFSTAE IRKDISAMEE EKDQLIKRVE HLKKRVETAQ NHQWMLKIAR QLRVEKEREE YLAQQKQEQK NQLFHAVQRL QRVQNQLKSM RQAAADAKPE SLMKRLEEEI KFNLYMVTEK FPKELENKKK ELHFLQKVVS EPAMGHSDLL ELESKINEIN TEINQLIEKK MMRNEPIEGK LSLYRQQASI ISRKKEAKAE ELQEAKEKLA SLEREASVKR NQTREFDGTE VLKGDEFKRY VNKLRSKSTV FKKKHQIIAE LKAEFGLLQR TEELLKQRHE NIQQQLQTME EKKGISGYSY TQEELERVSA LKSEVDEMKG RTLDDMSEMV KKLYSLVSEK KSALASVIKE LRQLRQKYQE LTQECDEKKS QYDSCAAGLE SNRSKLEQEV RRLREECLQE ESRYHYTNCM IKNLEVQLRR ATDEMKAYIS SDQQEKRKAI REQYTKNTAE QENLGKKLRE KQKVIRESHG PNMKQAKMWR DLEQLMECKK QCFLKQQSQT SIGQVIQEGG EDRLIL
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