Beta-catenin-like protein 1 (CTNNBL1)

About Beta-catenin-like protein 1

Beta-catenin-like protein 1 (CTNNBL1) is a protein from Homo sapiens identified by UniProt accession Q8WYA6, 563 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	Beta-catenin-like protein 1
UniProt accession	Q8WYA6
Gene	CTNNBL1
Organism	Homo sapiens
Length	563 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (124)

Diseases linked to this target (Open Targets).

immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.45
neurodegenerative disease · score 0.44
neoplasm · score 0.04
vital capacity · score 0.03
Obesity · score 0.03
infect · score 0.03
infection · score 0.03
melanoma · score 0.02
hair colour measurement · score 0.02
systemic juvenile idiopathic arthritis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WYA6-F1	alphafold	PREDICTED	87.30	—

Amino-acid sequence (563 residues)

MDVGELLSYQ PNRGTKRPRD DEEEEQKMRR KQTGTRERGR YREEEMTVVE EADDDKKRLL QIIDRDGEEE EEEEEPLDES SVKKMILTFE KRSYKNQELR IKFPDNPEKF MESELDLNDI IQEMHVVATM PDLYHLLVEL NAVQSLLGLL GHDNTDVSIA VVDLLQELTD IDTLHESEEG AEVLIDALVD GQVVALLVQN LERLDESVKE EADGVHNTLA IVENMAEFRP EMCTEGAQQG LLQWLLKRLK AKMPFDANKL YCSEVLAILL QDNDENRELL GELDGIDVLL QQLSVFKRHN PSTAEEQEMM ENLFDSLCSC LMLSSNRERF LKGEGLQLMN LMLREKKISR SSALKVLDHA MIGPEGTDNC HKFVDILGLR TIFPLFMKSP RKIKKVGTTE KEHEEHVCSI LASLLRNLRG QQRTRLLNKF TENDSEKVDR LMELHFKYLG AMQVADKKIE GEKHDMVRRG EIIDNDTEEE FYLRRLDAGL FVLQHICYIM AEICNANVPQ IRQRVHQILN MRGSSIKIVR HIIKEYAENI GDGRSPEFRE NEQKRILGLL ENF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards